By Henry L. Foster, J. David Small, James G. Fox
Ailments -- quantity II of The Mouse in Biomedical learn. Compiles for the 1st time in a single layout a story detailing infectious ailments of the mouse.
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Extra resources for Diseases. The Mouse in Biomedical Research
Early in the c o u r s e of the d i s e a s e , the m a i n lesion is suppurative rhinitis. Respiratory and olfac tory e p i t h e l i u m m a y u n d e r g o d r a m a t i c c h a n g e to a s q u a m o i d a p p e a r a n c e during the m o r e acute p h a s e s of the disease (Pigs. 1-4). Syncytial giant cells frequently occur in the e p i t h e l i u m (Pigs. 5 and 6 ) . Often there is h y p e r p l a s i a of the s u b m u c o s a l glands suggesting increased secretion (Pigs. 2 and 3 ) .
Fig. 4. Right side of the nasal septum depicted in Fig. 1, showing normal olfactory epithelium. Numerous large and small nerve fibers (N) are present near the bony septum. x 3 7 5 . Fig. 5. Nasal passage of a mouse with suppurative rhinitis due to Mycoplasma pulmonis. Note the abundant purulent exudate in the lumen, lymphoid infiltrate in the submucosa of the scrolls, and syncytial giant cells in the surface epithelium. X l 2 0 . Fig. 6. Higher magnification of the tip of the nasal scroll shown in Fig.
II. III. IV. V. VI. VII. VIII. I. and Maureen K. Davidson Introduction Murine Respiratory Mycoplasmosis (MRM) A. Historical Background of MRM in the Mouse B. Characteristics of Mycoplasma pulmonis C. Experimental Disease D. Natural Disease and Pathology E. MRM Complicated by Other Infections 21 22 22 22 22 23 28 F. Immune Response G. Diagnosis H. Epizootiology I. Control J. Interference with Research Klebsiellosis Pasteurellosis A. Pasteurella pneumotropica, a Respiratory Tract Pathogen? B. Pasteurella pneumotropica, an Opportunistic Respiratory Tract Pathogen?