By CIBA Foundation Symposium
The time period ``unconventional virus'' refers to virus-like brokers that vary from traditional viruses in major respects--resistance to brokers that inactivate basic viruses, for instance. definite infrequent and deadly neurological issues, comparable to the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are in actual fact produced by means of virus-like infectious brokers, however the nature of those brokers isn't understood. This quantity brings jointly the newest details on one such illness: Scrapie, a affliction happening in sheep. It discusses the character of this infectious agent and insights won via new innovations in molecular genetics. The paintings as a complete makes a speciality of the consequences of animal facts for study on human problems, reminiscent of the potential connection among unconventional viruses and Alzheimer's illness. The discussions symbolize the paintings of experts from a vast spectrum of fields together with virology, neuropathology, and molecular biology.
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Extra resources for Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System
Acta Neuropathol 60:113-124 Merz PA, Somerville RA, Wisniewski HM 1983b Abnormal fibrils in scrapie and senile dementia of the Alzheimer type. In: Court LA, Cathala F (eds) Virus non conventionnels et affections du systeme nerveux central. Masson, Paris, p 259-281 Merz PA, Somerville RA, Wisniewski HM, Manuelidis L, Manuelidis EE 1983c Scrapie-associated fibrils in Creutzfeldt-Jakob disease. Nature (Lond) 306:474-476 Merz PA, Rohwer RG, Kascsak R, Wisniewski HM, Somerville RA, Gibbs CJ, Jr, Gajdusek DC 1984 Infection-specific particles from the unconventional slow virus diseases.
Our studies (Masters et a1 1985a,b) show that both types of amyloid are built from the same A4 subunit. It is highly probable that the precursor for A4 is cleaved and/or processed by different mechanisms giving rise to either the intracellular or extracellular filament. One such processing mechanism may be ubiquitination (Mori et al 1987, Perry et a1 1987). In different disease states there are unknown factors which drive the amyloidogenic pathway preferentially in one of the two directions (Guiroy et all987).
The fibrils narrow to 4-6 nm usually every 40-60 nm, although in some of the fibrils the narrowing is found every 80-110 nm. Within the fibril the space between the individual filaments can be observed for 40-60 nm along the length of the fibril between each narrow portion. . Type 2 is composed of four filaments with a space between each filament of 3-4 nm at its widest. The fibril measures 27-34 nm at its widest and 9-12 nm at its narrowest. ” I agree with Colin Masters that what he called SAF look like our preparations of prion rods (Prusiner et a1 1982, 1983).