By Farber J.M.
CCR6 is a seven transmembrane area G protein n-coupled receptor for MIP-3rt, a CC chemokine expressed by means of various telephone kinds, together with epithelial cells, based on inflammatory stimuli. CCR6 is expressed on reminiscence T cells, В cells, and CD34 I bone marrow progenitor-derived dendritic cells. CCR6 is energetic on resting reminiscence cells and will mediate either chemotaxis and adhesion of those cells to ICAM-1. it truly is presumed that CCR6 is curious about the recruitment of reminiscence T cells on the initiation of a reaction at inflammatory websites and/or in reactive lymphoid tissue. info additionally recommend that CCR6 on immature dendritic cells can be very important for the recruitment of those cells to inflammatory websites. because the MIP-Зл gene is additionally expressed in dendritic cells. CCR6 may well mediate aggregation of dendritic cells, reminiscence T cells, and В cells.
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