New PDF release: Cannabinoids and the brain

By Attila Köfalvi

Endocannabinoids have great healing capability. This ebook introduces readers to our present knowing of the neurobiology of endocannabinoids and comparable platforms, detailing their pathophysiological position and healing capability. Authors, skilled scientific investigators, current and study result of fresh medical trials in addition to the advance of recent healing suggestions and medicines.

Show description

Read Online or Download Cannabinoids and the brain PDF

Similar neuroscience books

New PDF release: New Frontier of Religion and Science: Religious Experience,

This is often the 1st significant reaction to the hot problem of neuroscience to faith. there were restricted responses from a in simple terms Christian perspective, yet this takes account of jap in addition to western varieties of non secular adventure. It demanding situations the existing naturalistic assumption of our tradition, together with the concept that the brain is both exact with or a short lived derivative of mind task.

Computational Neuroscience of Drug Addiction by Vladimir L. Tsibulsky, Andrew B. Norman (auth.), Boris PDF

Drug habit is still the most vital public illnesses in western societies and is a emerging hindrance for constructing countries. during the last three many years, experimental examine at the neurobiology and psychology of drug habit has generated a torrent of interesting info, from the molecular as much as the behavioral degrees.

Optical Imaging of Neocortical Dynamics by Bruno Weber, Fritjof Helmchen PDF

The applying of optical tools for investigating neocortical circuit dynamics has significantly extended in recent times, delivering novel insights into the attention-grabbing global of mind functionality. Optical Imaging of Neocortical Dynamics offers a advisor to those indispensible instruments, which conceal a extensive variety of spatiotemporal scales and a wide number of signaling elements, starting from voltage alterations to metabolic states.

Additional info for Cannabinoids and the brain

Example text

2004); hreviewed in Fowler et al. (2005); iDeutsch et al. (2001); jKaczocha et al. (2006); kThors and Fowler (2006); lRamakrishnan et al. (2002); mFowler et al. J. Fowler and L. Thors Fig. 2 Comparison of potencies for a series of AEA head group analogues (a) and a series of compounds with different primary structures (b) with respect to inhibition of FAAH and inhibition of AEA uptake. In (a), the data are taken from Jarrahian and colleagues (2000) and the inhibition of rat forebrain FAAH is compared with the inhibition of AEA uptake into rat cerebral granule cell cultures (2-min incubation period).

2006). , the hydrolysis of phosphatidylinositol (PI) by phospholipase A1 and hydrolysis of the resultant lysoPI by a specific phospholipase C, were studied by Okuyama and coworkers in the mid-1990s. , 1994). It seems possible, therefore, that this unique enzyme is involved in the metabolism of lysoPI and the generation of lysoPI-derived lipid molecules such as 2-AG in the synapses. (c) 2-AG can also be formed through the conversion of 2-arachidonoyl lysophosphatidic acid (LPA) to 2-AG (Fig. 2).

Melis M, Perra S, Muntoni AL, Pillolla G, Lutz B, Marsicano G, Di Marzo V, Gessa GL, Pistis M (2004) Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci 24:10707–10715. Moesgaard B, Petersen G, Jaroszewski JW, Hansen HS (2000) Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain. A 31P NMR and enzyme activity study. J Lipid Res 41:985–990. Moesgaard B, Petersen G, Mortensen SA, Hansen HS (2002) Substantial species differences in relation to formation and degradation of N-acyl-ethanolamine phospholipids in heart tissue: an enzyme activity study.

Download PDF sample

Rated 4.49 of 5 – based on 32 votes