New PDF release: Brain Tumors: Their Biology and Pathology

By Klaus J. Zülch M.D., Dr. h.c. (auth.)

The 3rd American variation has been thoroughly revised and improved, even though components of the textual content of the second one variation were integrated. I desire to recognize once more the wonderful translation of the previous variants by way of Dr. ALAN B. ROTHBALLER and the past due Dr. JERZY OLSZEWSKI. With this version i've got the final subject matter of the unique German variation released in 1951. in spite of the fact that, i've got attempted to think about sleek ideas and the various new guides almost about mind tumors. in the meantime, an early hope of mine has been fulfilled via the of entirety and ebook of a type which are understood around the world and optimistically be used extensively, specifically, the classi­ fication of the realm wellbeing and fitness association: Histological Typing of Tu­ mours of the valuable frightened process (1979). The type which I utilized in the 1951 variation is especially with reference to the ultimate development of that accredited via the area health and wellbeing association (WHO), for the reason that either stick to the road of the BAILEY and CUSHING classifica­ tion of 1926/1930. To consolidate our outdated options and studies we've reclassi­ fied our number of 9000 instances with the help of my co-workers Dr. M. FUKUI, Dr. A. SATO. Dr. E. SCHARRER, Dr. E. SIMON, and Dr. J. SZYMAS. within the final decade huge atlases were released, one referred to as an Atlas of the Histology of mind Tumors 1 (in six languages) and a moment one referred to as an Atlas of the Gross Neurosurgical Pathology 2.

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A similar transformation was observed in one of our cases of oligodendroglioma (SCHUlER 1976) in which focal seizures developed in a 21-year-old woman patient without any detectable radiologic focus. The seizures were medically controlled for 8 years after which a temporal oligodendroglioma was diagnosed and surgically removed. The histologic appearance was that of an isomorphous oligodendroglioma. At autopsy 2-} years later the appearance in some areas still persisted with the same pattern but in other areas was transformed into a neoplasm which almost entirely consisted of nuclear material where the highest degree of pleomorphism and anaplasia was visible; yet, it was a focal anaplasia.

The latter are angiographically demonstrable as early filling veins or observed during surgery as "red" veins. A few features will be discussed in more detail. In the formation of metastases we differentiate seeding by way of the CSF (meningeal and ventricular) and through the blood system (hematogenous). The latter is a sign of high malignancy and is observed particularly in medulloblastomas and occasionally even in glioblastomas, as well as in rarer entities such as monstrocellular sarcomas. It will be described below that spontaneous seeding along the CSF pathway - so common in medulloblastomas, pineoblastomas, meningeal sarcomas - occasionally also occurs in relatively benign tumors such as oligodendrogliomas, ependymomas, and choroid plexus papillomas, etc.

64) which grew within the frontal, parietal, and temporal lobes. We also described the temporobasal very benign gangliocytomas (GP, Fig. 51) occurring in the same age group (TONNIS and ZULCH 1939). In addition I was able to add here the ependymomas of the foramen of Monro in middle age (GP, Fig. 55), described with SCHMID (ZULCH and SCHMID 1955); the typical oligodendrogliomas (ZULCH 1941 a) of middle age (Figs. 57, 59), located in the second and third frontal convolution; and finally the thalamic oligodendroglioma of adolescence (GP, Fig.

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