By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology
Are environmental pollution threatening the human immune process? Researchers are speedily coming near near definitive solutions to this question, through biologic markers - subtle evaluation instruments that can revolutionize detection and prevention of sure ailments. This quantity, 3rd in a chain on biologic markers, makes a speciality of the human immune procedure and its reaction to environmental toxicants. The authoring committee offers course for carrying on with improvement of biologic markers, with concepts for utilizing markers to immunotoxicology in people and advised outlines for medical and box stories. This complete, up to date quantity may be important to experts in toxicology and immunology and to biologists and investigators concerned with the improvement of biologic markers.
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Extra info for Biologic Markers in Immunotoxicology
Choosing among multiple markers requires attention to the appropriate statistical approaches that assist in the determination of whether the markers are statistically independent of one another. The complex interactions of the immune system require that a judgment be made of whether immunologic markers are biologically independent and should be treated as statistically independent or statistically correlated. Confounding factors can be controlled in epidemiologic study designs by restriction or matching and in analyses by stratification or multivariate methods.
Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. html INTRODUCTION 12 that will elucidate the relationship between environmental exposures and human diseases, so that such exposures and diseases can be prevented. Early detection that leads to prevention of disease and of disability is the ultimate goal and promise of the use of biologic markers.
Biologic markers often are elucidated by clinical laboratory measurements or clinical tests used in the differential diagnosis of various diseases. The markers can serve as surrogates for other methods of detection in determining the molecular and cellular events in the development of health problems. If such markers could be detected before exposed persons became obviously ill, the disease process might be reversed in those affected or prevented in others. In addition, some cellular or molecular measurements can identify people who are more vulnerable to the effects of toxic exposure; these are markers of susceptibility.