By Joseph Marr, Miklos Muller
The research of parasitic organisms on the molecular point has yielded interesting new insights of significant scientific, social, and least expensive significance, and has pointed the best way for the therapy and prevention of the ailments they reason. Biochemistry and Molecular Biology of Parasites provides an up to date account of this contemporary medical self-discipline in a fashion that permits and encourages the reader to put the biochemistry and molecular biology of those organisms of their organic context. The chapters are cross-referenced and grouped in an association that offers an absolutely built-in complete, and allows the reader to create a composite of the biochemical functionality of those organisms.
Individual bankruptcy comprises these dedicated to metabolism, in either cardio and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are mentioned not just from the viewpoint in their mobile biochemistry and metabolism, but in addition with recognize to either their built-in features comparable to neurochemistry, constitution and features of surfaces, and copy. Written via professional investigators, this publication could be of curiosity to all skilled researchers, graduate scholars, and to the newcomer desirous to familiarize yourself with the biochemistry and molecular biology of parasites.
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Additional info for Biochemistry and Molecular Biology of Parasites
Hyperosmotic stress also alters the fluxes through the pathways of intermediary metabolism by increasing pyruvate, alanine and D-lactate production and by decreasing the production of acetate and succinate. The net result is an increase in the intracellular pool size of alanine, which counteracts the loss of water and reduction in cell volume that would otherwise occur (15). Studies of the carbohydrate metabolism of T. cruzi (21) have shown that phosphoenolpyruvate serves as the acceptor of the primary CO2-fixation reaction.
Biochem. Parasitol. 47: 1-10. 35. , Kuntz, D. A. and Opperdoes, F. R. (1991) Characterization of pyruvate kinase of Trypanosoma brucei and its role in the regulation of carbohydrate metabolism. Mol. Biochem. Parasitol. 47:19-30. 36. Callens, M. and Opperdoes, F. R. (1992) Some kinetic properties of pyruvate kinase from Trypanosoma brucei. Mol. Biochem. Parasitol. 50: 235-244. 37. Krakow, J. L. and Wang, C. C. (1990) Purification and characterization of glycerol kinase from Trypanosoma brucei. Mol.
And Opperdoes, F. R. (1986) Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties. Eur. J. Biochem. 157: 441-453. 27. Misset, O. and Opperdoes, F. R. (1984) Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei. Eur. J. Biochem. 144: 475-483. 28. Misset, O. and Opperdoes, F. R. (1987) The phosphoglycerate kinases from Trypanosoma brucei: a comparison of the glycosomal and cytosolic isoenzymes and their sensitivity towards suramin.