New PDF release: Autism Spectrum Disorders - From Genes to Environment

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Extra resources for Autism Spectrum Disorders - From Genes to Environment

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On the other hand, children with Asperger disorder may not have clear difficulties in communication. Their language may actually be characterized by a particularly correct speech. There is no available drug designed for improving the capacity of communication capacity in ASD patients. The best treatment for this problem is provided by speech therapy (Rotta and Riesgo, 2005). The repetitive and stereotyped patterns of behavior, characteristic of autism include resistance to any sort of changes, the insistence on certain routines, the excessive attachment to objects and the fascination with the movement of parts, such as wheels or propellers.

In this way we will be able to determine the molecular and cell biological effects of the A-C haplotype throughout development. Because the human sequence will include the flanking CpG islands, we will also be able to expose the mice to various non-genetic factors that affect epigenetic regulation and investigate how these environmental compounds can either improve or worsen the A-C associated phenotypes. 8. Summary We have demonstrated that the EN2 rs1861972-rs1861973 A-C haplotype is significantly associated with ASD in 3 datasets.

Acknowledgements We thank NICHD Brain and Tissue Bank for Developmental Disorders, the Harvard Brain Tissue Resource Center for the post-mortem samples, and all participating families for the post-mortem samples. We thank the Autism Tissue Program and especially Jane Pickett for all their help. We acknowledge the funding agencies that have supported this research: NIH (MH076624, MH080429, MH083509), Department of Defense (W81XWH-09-1-0286), NAAR/Autism Speaks, and New Jersey Governor’s Council for Medical Research and Treatment of Autism 10.

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