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36. Hall B, Kallen B: Chromosome studies in abortuses and stillborn infants. Lancet 1:110, 1964. 37. Boue J, Boue A, Lazar P: The epidemiology of human spontaneous abortions with chromosomal anomalies. In: Aging Gametes. RJ Blandau, ed. Karger, Basel, 1975, p. 330. 38. : Chromosome abnormalities in spontaneous 17 18 X-LINKED MENTAL RETARDATION 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. abortion: data from the New York City study. In: Human Embryonic and Fetal Death.

Langer PR, Waldrop AA, Ward DC: Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes. Proc Natl Acad Sci USA 78:6633, 1981. Speicher MR, Ballard SG, Ward DC: Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat Genet 12:368, 1996. : Multicolor spectral karyotyping of human chromosomes. Science 273:494, 1996. Gardiner K: Base composition and gene distribution critical patterns in mammalian genome organization. Trends Genet 12:519, 1996. McKusick VA: On the X Chromosome of Man.

Whites and blacks were alike in this regard. Among whites, the excess of males was 25%; among blacks, the excess was 21%. 9'81 Referred to as the Colchester Survey, the study included 1280 institutionalized individuals with a wide range of mental retardation. Males outnumbered females among all severities of mental retardation except those with IQs above 70 who were deemed mentally retarded because of antisocial behavior (Table 2-4). The male excess was correlated directly with the severity of TABLE 2-4.

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