By Jacques Descotes
This article offers a concise and finished creation to key immunotoxicological matters for all these drawn to, yet without previous wisdom of, this sector of toxicology. the 1st part explores the future health outcomes of immunotoxicity, particularly the antagonistic results regarding chemically-induced immunosuppression and immunostimulation, allergy reactions and autoimmune ailments, with an outline of significant immunotoxicants. the second one half describes the most recent tools used to notice and assessment, preclinically and clinically, the unforeseen immunotoxic results of xenobiotics. traits in enforcing thoughts and up to date alterations to the regulatory elements also are thought of. The 3rd part examines attainable destiny advancements, together with In Vitro equipment, biomarkers of immunotixicity and danger review.
Read Online or Download An introduction to immunotoxicology PDF
Best toxicology books
The swiftly evolving box of environmental toxicology contains the learn of poisonous compounds and their impact on dwelling organisms, in addition to their destiny in the typical surroundings. because ebook of the 1st variation, advent to Environmental Toxicology has came across a safe position one of the significant texts and references during this box.
The concept that of circulate injection research (FIA) was once first proposed in 1975 by way of Ruzicka and Hansen, and this initiated a box of study that will, over greater than 3 many years, contain millions of researchers, and which has to this point ended in with reference to 20,000 guides within the overseas medical literature.
New study, outbreaks of foodborne affliction and alterations to laws suggest that meals microbiology learn is a consistently evolving box. The editor and participants summarize the main tendencies during this sector for the nutrition undefined. The booklet starts with an interview with nutrients safeguard professional Bruce Tompkin and serves as a survey of meals security administration platforms from the prior to the current day and destiny nutrients security demanding situations.
Platforms Biology in Environmental health and wellbeing: From the Genome to the Epigenome brings a structures organic standpoint to fresh findings that hyperlink environmental exposures to human affliction. as well as introductory chapters on molecular and mobile biology, toxicology, and computational biology, the ebook presents an evaluation of systems-based instruments that assessment environmental healthiness dangers.
- Drug Therapy During Pregnancy
- a worldwide yearly survey of new data and trends in adverse drug reactions
- Handbook of Food Toxicology (Food Science and Technology)
- Managing the laboratory animal facility
Extra info for An introduction to immunotoxicology
Bacterial infections are preferentially due to staphylococci (Staphylococcus aureus and S. epidermidis), streptococci (Streptococcus pneumoniae), Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes, Haemophilus influenzae, Nocardia, and Mycobacteria (Donnelly, 1995). L. monocytogenes is an intracellular pathogen that occurs in patients with a defect in cellular immunity. Meningitis is the most common complication, but bacteraemia, brain abscess, meningo-encephalitis, or pneumonia may also develop.
Other terms, such as immunorestoration or immune-enhancement, have also been commonly used, but these linguistic differences are more likely to reflect limitations in our current understanding of the potential for pharmacological immunomanipulation or immunostimulation than a scientifically established situation. Overall, the adverse consequences of immunostimulation on human health have been less extensively investigated than those of immunosuppression, because immunosuppression has been an issue of primary concern for immunotoxicologists during the past 20 years, but also because potent immunostimulating agents, such as the recombinant cytokines interferon␣ and IL-2, were introduced into the clinical setting only recently.
Illustrative examples from the general medical practice include infants born with a severe immune defect, and cancer or AIDS patients, all of whom develop frequent, severe and potentially lethal infections (Rubin and Young, 1994). Similar examples can be found in the area of toxicology. Infectious complications have long been described in patients treated with long-term and/or high-dose corticosteroid therapy (Kass and Finland, 1953; Thomas, 1952), immunosuppressants or cytotoxic anticancer drugs (Davies, 1981).