Download e-book for kindle: Adenoviruses. Basic Biology to Gene Therapy by Prem Seth

By Prem Seth

Ever on account that their discovery, adenoviruses have confirmed to be tremendousasset to biologists. during the examine of the adenoviruses theauthors have realized not just in regards to the virus buildings, mechanismsof viral replication, but additionally approximately eukaryotic gene expression,alternative splicing, law of telephone cycle development, andapoptosis. within the final 5 years, there was an explosion within the use of adenoviruses as vectors for gene move to a number of mammalian cells. Adenoviral vectors also are being validated in section I scientific trials for cystic fibrosis and for lots of forms of cancers. those fresh advancements in using adenoviral vectors for gene treatment have rejuvenate an curiosity within the simple technology of adenovirus examine. extra importantly, it has generated a need for a unmarried quantity that covers either the biology of adenoviruses aswell as our development within the use of adenoviruses as vectors for gene treatment. This e-book was once written accurately to meet any such want.

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J Virol 1981; 39(3):977-980. 20. Ghosh-Choudhury G, Haj-Ahmad Y, Graham FL. Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes. EMBO J 1987; 6(6):1733-1739. 21. Burnett RM. The structure of the adenovirus capsid. II. The packing symmetry of hexon and its implications for viral architecture. J Mol Biol 1985; 185(1):125-143. 22. Everitt E, Lutter L, Philipson L. Structural proteins of adenoviruses. XII. Location and neighbor relationship among proteins of adenovirion type 2 as revealed by enzymatic iodination, immunoprecipitation and chemical cross-linking.

4. van Oostrum J, Burnett RM. Molecular composition of the adenovirus type 2 virion. J Virol 1985; 56(2):439-448. 5. Burnett RM. Structural investigations on hexon, the major coat protein of adenovirus. In: Jurnak F, McPherson A, eds. Biological Macromolecules and Assemblies. New York, NY: John Wiley & Sons; 1984:337-385. 6. Stewart PL, Fuller SD, Burnett RM. Difference imaging of adenovirus: Bridging the resolution gap between X-ray crystallography and electron microscopy. EMBO J 1993; 12(7):2589-2599.

Isolation of Ad5 host-range deletion mutants defective for transformation of rat embryo cells. Cell 1979; 17:683-689. 28. Dou S, Zeng X, Cortes P et al.

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