David O. Cooney's Activated Charcoal in Medical Applications, Second Edition PDF

By David O. Cooney

Highlighting activated charcoal's nice effectiveness in treating drug overdoses and poisonings in either people and animals, this entire, single-source reference brings jointly important info from each major learn at the use of activated charcoal for clinical purposes-describing all on hand charcoal items and their features.

Details activated charcoal's skill to minimize the systemic absorption of an enormous array of gear, chemical substances, and biochemical substances-including analgesics, antipyretics, sedatives, alkaloids, snake venoms, and bacterial and fungal pollution.

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Additional resources for Activated Charcoal in Medical Applications, Second Edition

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However, since in all cases of interest to us the solvent will be water, we need not consider solvent effects further. C. Surface Area of the Charcoal At first thought, the amount of substance which a charcoal can adsorb would seem to be directly proportional to the internal surface area. Yet such is not always true. One must be aware that the surface area is usually inferred from the amount of N 2 (a small molecule) which can be adsorbed at -196°C (N2 boiling point). If one wishes to adsorb a large molecule, much of the internal surface area may not be accessible.

113, 99. Irgang, I. (1927). Some comparative investigations of medicinal carbon preparations, Dansk. Tids. Farm. 7, 167. Joachimoglu, G. (1916). Adsorption capacity of animal charcoal and its determination, Biochem. Z. 77, 1. Joachimoglu, G. (1920). -Ztg. 44, 780. Joachimoglu, G. (1923). Adsorption and detoxification power of certain charcoals, Biochem. Z. 134, 493. Keeser, E. (1924). Adsorption and the distribution of drugs in the organism. IE, Biochem. Z. 144, 536. Kehls, D. M. (1793). Memoire sur le charbon v6g6tal, observations et journal sur la physique, de chemie et l'histoire naturelle et des arts, Paris, Tome XLII, 250.

The external area defines the amount of contact area between the charcoal and a surrounding solution. The rate of transfer of adsorbable molecules from the fluid phase to the charcoal phase will be proportional to the external area; in contrast, the internal surface area determines the amount of adsorption that can occur at equilib­ rium. To reiterate, external surface area determines the rate of adsorption and internal surface area determines the amount of adsorption. D. Nature of the Charcoal Surface A very extensive discussion of the nature of the charcoal surface, how it depends on the conditions used to activate the charcoal, and how these surface properties affect the adsorption behavior of charcoals has been given in a book by Mattson and Mark (1971) entitled Activated Carbon: Surface Chemistry and Adsorption from Solution and will not be repeated here in any detail.

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