Read e-book online A Textbook of Modern Toxicology, 4th Edition PDF

By Ernest Hodgson

A Textbook of recent Toxicology is a special source that offers either scholars and practitioners with a wide-ranging, obtainable review of the self-discipline. compatible for classes in environmental, pharmacological, clinical, and veterinary toxicology, this crucial textual content positive factors chapters written via specialists who deal with a variety of key topics.The Fourth version contains extra chapters on new ways to toxicology - molecular tools (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and structures biology – and keeps the legacy of its predecessors to supply up to date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity trying out, ecological danger evaluation, and plenty of different components of toxicology that aid foster an outstanding comprehension of the field.Also featured within the Fourth variation are end-of-chapter questions and a recommendations handbook on hand individually for tutorial adopters.

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Extra info for A Textbook of Modern Toxicology, 4th Edition

Example text

One incident occurred in 1948 in Donora, a small steel mill town in western Pennsylvania. In late October, heavy smog settled in the area, and a weather inversion prevented the movement of pollutants out of the valley. Twenty-one deaths were attributed directly to the effects of the smog. The “Donora episode” helped focus attention on air pollution in the United States. A Textbook of Modern Toxicology, Fourth Edition. Edited by Ernest Hodgson Copyright © 2010 John Wiley & Sons, Inc. 31 32 TOXICANTS IN AIR, WATER, SOIL, DOMESTIC, AND OCCUPATIONAL SETTINGS In London in December 1952, the now infamous killer smog occurred.

In the group of sciences to which toxicology contributes significantly are such aspects of medicine as forensic medicine, clinical toxicology, pharmacy, and pharmacology, public health, and industrial hygiene. Toxicology also contributes in an important way to veterinary medicine, and to such aspects of agriculture as the development and safe use of agricultural chemicals. The contributions of toxicology to environmental studies have become increasingly important in recent years. 10 INTRODUCTION TO TOXICOLOGY Clearly, toxicology is preeminently an applied science, dedicated to the enhancement of the quality of life and the protection of the environment.

Biochemical and molecular toxicology consider events at the biochemical and molecular levels, including enzymes that metabolize xenobiotics, generation of reactive intermediates, interaction of xenobiotics or their metabolites with macromolecules, gene expression in metabolism and modes of action, signaling pathways in toxic action, and so on. 2. Behavioral toxicology deals with the effects of toxicants on animal and human behavior, which is the final integrated expression of nervous function in the intact animal.

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